NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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Which medication is used for MRSA decolonization?

  1. Mupirocin

  2. Daptomycin

  3. Linezolid

  4. Nafcillin

The correct answer is: Mupirocin

Mupirocin is the correct answer for MRSA decolonization because it is a topical antibiotic that is effective against Staphylococcus aureus, including methicillin-resistant Staphylococcus aureus (MRSA). When applied to the nasal passages, mupirocin can reduce the carriage of MRSA in the nares and help prevent the spread of the bacteria to other parts of the body or to other individuals. Daptomycin, Linezolid, and Nafcillin are not typically used for MRSA decolonization. Daptomycin and Linezolid are antibiotics that are usually reserved for treating infections caused by MRSA rather than for decolonization purposes. Nafcillin is a beta-lactam antibiotic that is not effective against MRSA due to its resistance to beta-lactam antibiotics.