NAPLEX Practice Exam 2025 – Comprehensive Test Preparation

Question: 1 / 1820

What is the recommended perioperative antibiotic for cardiac or vascular surgery?

Cefazolin or cefuroxime

In general, the recommended perioperative antibiotic for cardiac or vascular surgery is cefazolin or cefuroxime. This is because these antibiotics have a broad spectrum of coverage against common pathogens and have been shown to effectively prevent surgical site infections. Clindamycin or vancomycin may be used for patients with a documented allergy to beta-lactams, but they are not the recommended choice initially. Using cefazolin alone may be insufficient in some cases, as it may not cover certain types of bacteria commonly found in the surgical environment. Adding metronidazole may be necessary if the surgery involves the gastrointestinal tract, but it is not routinely recommended for all cardiac or vascular surgeries. Therefore, option A is the best choice for the recommended perioperative antibiotic in these surgeries.

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Clindamycin or vancomycin for beta-lactam allergy

Cefazolin alone

Cefazolin + metronidazole

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