What is a major concern associated with opioids according to the boxed warnings?

Weight gain

Addiction, abuse, misuse leading to overdose and death

Opioids have been found to carry a highly addictive potential, leading to abuse and misuse by individuals. This can result in an overdose, which can ultimately lead to death. This is the major concern associated with opioids and is highlighted by boxed warnings. Weight gain, muscle growth, and improved cardio health are not typically associated with opioids and are not mentioned as concerns in the boxed warnings.

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Muscle growth

Improved cardio health

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