NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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Which medication is NOT used in ischemic stroke secondary prevention?

  1. Aspirin

  2. Clopidogrel

  3. Alteplase

  4. Dipyridamole/aspirin

The correct answer is: Alteplase

Alteplase is not used in ischemic stroke secondary prevention because it is a thrombolytic agent indicated for the treatment of acute ischemic stroke within the first few hours of symptom onset, rather than for long-term prevention. Thrombolytics like alteplase work by breaking down blood clots that are causing the stroke, but they are not used for ongoing prevention of future strokes. As for the other options: - Aspirin and dipyridamole/aspirin are commonly used in ischemic stroke secondary prevention as antiplatelet agents to reduce the risk of clot formation. - Clopidogrel is another antiplatelet agent that is also used in ischemic stroke prevention in patients who cannot tolerate aspirin or have recurrent strokes despite aspirin therapy.