NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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Which medication combination is used for systemic hormone therapy in menopause to address both estrogen and progesterone needs?

  1. Conjugated equine estrogens + medroxyprogesterone

  2. Estradiol + Micronized progesterone

  3. Conjugated equine estrogens

  4. Medroxyprogesterone

The correct answer is: Conjugated equine estrogens + medroxyprogesterone

Estradiol and micronized progesterone (answer B) is incorrect because it only addresses estrogen and not progesterone. Conjugated equine estrogens (answer C) and medroxyprogesterone (answer D) are also incorrect because they only address either estrogen or progesterone, but not both. The correct combination is conjugated equine estrogens + medroxyprogesterone (answer A), as it addresses the needs for both hormones in menopausal women.

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