NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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What does voxelotor do in the treatment of sickle cell disease?

  1. Increases white blood cell count

  2. Inhibits hemoglobin S polymerization

  3. Promotes iron absorption

  4. Reduces kidney damage

The correct answer is: Inhibits hemoglobin S polymerization

Voxelotor, also known by the brand name Oxbryta, is a medication used in the treatment of sickle cell disease. The correct answer is that voxelotor inhibits hemoglobin S polymerization. In sickle cell disease, hemoglobin S polymerizes under conditions of low oxygen, leading to the characteristic sickling of red blood cells. By inhibiting this process, voxelotor helps prevent the sickling of red blood cells and related complications. Option A, increasing white blood cell count, is unrelated to the mechanism of action of voxelotor. Option C, promoting iron absorption, is also not associated with voxelotor. Option D, reducing kidney damage, is not a direct effect of voxelotor in the treatment of sickle cell disease.