NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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Prepare to ace the NAPLEX. Utilize flashcards and multiple choice questions with hints and explanations. Equip yourself thoroughly for the exam!

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How is the elimination rate constant (Ke) calculated?

Cl x Vd
Cl/Vd
Vd/Cl
Vd x Cl

The correct answer is: Cl/Vd

The elimination rate constant (Ke) is calculated by taking the clearance (Cl), which is the rate at which a drug is removed from the body, and dividing it by the volume of distribution (Vd), which is the apparent space in the body available to contain the drug. This is because the elimination rate constant represents the efficiency of drug clearance from the body in relation to the apparent space it occupies, so it is important to take into consideration both the clearance and volume of distribution. The incorrect options (A, C, and D) involve multiplying the clearance and volume of distribution, which does not yield the correct result for the elimination rate constant.