NAPLEX Practice Exam 2025 – Comprehensive Test Preparation

Question: 1 / 1820

Which medication has a black box warning for respiratory depression in children?

Dextromethorphan

Guaifenesin

Codeine

Codeine is the correct answer as it has a black box warning for respiratory depression in children. Codeine is metabolized to morphine in the body by the CYP2D6 enzyme, which can result in higher morphine levels in some individuals, especially children, leading to potentially life-threatening respiratory depression. This is why it is crucial to avoid codeine use in children, particularly after tonsillectomy and/or adenoidectomy procedures due to an increased risk of respiratory adverse events.

Dextromethorphan is a cough suppressant commonly used in over-the-counter cough and cold medications. Guaifenesin is an expectorant used to help loosen mucus in the airways. Benzonatate is a non-narcotic cough suppressant used for symptomatic relief of cough. None of these medications have a black box warning for respiratory depression in children like codeine does.

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Benzonatate

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