NAPLEX Practice Exam 2026 – Comprehensive Test Preparation

Oritavancin is an antibiotic used to treat infections. It is a lipoglycopeptide antibiotic, which is a class of antibiotics that work by disrupting the cell wall of bacteria. This disruption can lead to certain adverse effects, such as QT prolongation and increased risk of C. diff, which are common with this type of antibiotic. However, what makes Oritavancin unique is that it should be avoided in patients with osteomyelitis, a bone infection. This is because Oritavancin has poor penetration into bone, thus making it ineffective for treating osteomyelitis. Therefore, the correct answer is A. The other options, B, C, and D, are all possible adverse effects or drug interactions with Oritavancin, but they are not unique to this medication.