NAPLEX Practice Exam 2025 – Comprehensive Test Preparation

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Question: 1 / 1820

Which of the following Azole antifungals penetrates the CNS?

Fluconazole

Fluconazole is the correct answer because it is the only Azole antifungal in the list that penetrates the central nervous system (CNS) effectively. Fluconazole has excellent penetration into the cerebrospinal fluid, making it a preferred choice for treating fungal infections in the CNS such as cryptococcal meningitis. The other options, Itraconazole, Voriconazole, and Ketoconazole, have minimal penetration into the CNS compared to Fluconazole and are not typically used for CNS fungal infections.

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Itraconazole

Voriconazole

Ketoconazole

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