NAPLEX Practice Exam 2026 – Comprehensive Test Preparation

Lipophilic antibiotics have an excellent tissue penetration because they can easily cross cell membranes due to their lipid solubility. This characteristic allows them to reach and concentrate in various tissues where the infection may be located, leading to an effective treatment. Poor tissue penetration (Option A) is not a characteristic of lipophilic antibiotics. Lipophilic antibiotics tend to have a larger volume of distribution as they distribute extensively into tissues (Option D). Renal elimination (Option C) is not a common characteristic of lipophilic antibiotics, as they are often metabolized by the liver.