NAPLEX Practice Exam 2025 – Comprehensive Test Preparation

Question: 1 / 1820

What is the treatment of choice for severe SSTIs in hospital settings?

Ceftaroline

Ceftaroline is the correct answer for the treatment of choice for severe SSTIs in hospital settings due to its broad spectrum of activity against Gram-positive bacteria including MRSA. Ceftaroline is a fifth-generation cephalosporin with activity against methicillin-resistant Staphylococcus aureus (MRSA) and Streptococcus pneumoniae. It is particularly effective in treating complicated skin and soft tissue infections where MRSA is a concern. Amoxicillin and Macrodantin are not typically the treatment of choice for severe SSTIs in a hospital setting due to limited antimicrobial spectrum and efficacy. Mupirocin is an antibacterial used for the treatment of impetigo and nasal decolonization of MRSA; it is not typically used as the primary treatment for severe SSTIs in a hospital setting.

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Amoxicillin

Mupirocin

Macrodantin

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