NAPLEX Practice Exam 2025 – Comprehensive Test Preparation

Question: 1 / 1820

Which medication has the highest COX-2 selectivity?

Celecoxib (Celebrex)

Celecoxib (Celebrex) has the highest COX-2 selectivity among the options provided. COX-2 inhibitors like celecoxib selectively inhibit the cyclooxygenase-2 enzyme, which is responsible for inflammation and pain, while sparing the cyclooxygenase-1 (COX-1) enzyme that helps maintain the stomach lining and normal platelet function. This selectivity helps reduce the risk of gastrointestinal ulcers and bleeding compared to non-selective NSAIDs like diclofenac, meloxicam, and ibuprofen. Thus, celecoxib is preferred in patients who are at higher risk of gastrointestinal complications.

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Diclofenac (Voltaren)

Meloxicam (Mobic)

Ibuprofen (Advil)

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