NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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For which DMARD is a contraindication listed as sulfa/salicylate allergy?

  1. MTX (Trexall)

  2. Hydroxychloroquine

  3. Sulfasalazine

  4. Leflunomide

The correct answer is: Sulfasalazine

A sulfa/salicylate allergy is a potential contraindication for Sulfasalazine, as it contains sulfapyridine, a sulfa derivative. MTX (Trexall) and Leflunomide do not contain sulfa or salicylate and are not typically contraindicated for patients with a sulfa/salicylate allergy. While Hydroxychloroquine does not contain sulfa, it does contain a derivative of salicylate, so it may be contraindicated for some patients with a sulfa/salicylate allergy. Therefore, C is the only correct answer as it directly addresses the contraindication for sulfa/salicylate allergy.